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Gong H, Xie J, Zhang N, Yao L, Zhang Y
Antioxidants that limit ROS production have been shown to inhibit TNF-induced necroptosis [128, 129], suggesting that ROS play a role in mediating necroptosis (Fig
Glutathione synthesis requires both glycine and cysteine , and these are in short supply in older humans
Another reason may be (ii) the specificity of the given antioxidant in protecting only certain types of target structures against certain types of ROS (e.g., vitamin E is effective at protecting membranes against peroxidation but not against DNA damage)
