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Specifically, polymorphisms in the Na V 1.4 (SCN4A-rs2302237) and Na V 1.8 genes (SCN10A-rs1263292) have been associated with increased incidence of acute oxaliplatin-induced neuropathy (Argyriou et al., 2013a), while patients carrying a polymorphism (rs6746030) in the SCN9A gene encoding for Na V 1.7 seem to develop less severe neuropathy than patients carrying other SCN9A gene variants (Sereno et al., 2017)