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For instance, in chimeric human cerebral organoids (chCOs), astrocytes and neurons carrying the APOE4 genotype could jointly promote tau phosphorylation in neurons, closely linked to the role of APOE4 in increasing cholesterol levels and lipid droplet content, suggesting that APOE4 may affect tau phosphorylation in AD by influencing lipid metabolism

10.3390/antiox10091407 [DOI] [PMC free article] [PubMed] [Google Scholar] Breijyeh Z., Karaman R

Reduction of L-DOPA-induced dyskinesia by the selective metabotropic glutamate receptor 5 antagonist 3-[(2-methyl-1,3-thiazol-4-yl)ethynyl]pyridine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-lesioned macaque model of Parkinson's disease

a) Overlap of the 16/SjGST cocrystal structure (PDB: 8GYD, with compound 16 depicted in green, SjGST in blue, and key residues shown in a gray sticks) with the IBZGSH/SjGST structure (PDB: 1M9B, where IBZGSH is shown in magenta and SjGST is represented by orange lines)