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Among several pathways, TGF- signaling has been reported to induce N-cadherin expression, a terminal differentiation marker of the PT cells [48], and Wnt/-catenin is crucial in kidney development and -catenin participates in the cellular structure integrity by linking cadherins to the actin cytoskeleton [49, 50]

Decreased levels of GSH have been noted in alcoholics, smokers, and patients with chronic liver disease [13]

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The peroxidation of cell membrane lipids, triggered by iron and the inactivation of antioxidant pathways, results in the accumulation of lipid peroxides and reactive oxygen species (ROS), causing cell membrane rupture and cell death