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This makes NAC an important addition to any glutathione-boosting regimen

Regarding liver and kidney damage in MTX treatment, Bedoui stated that MTX hepatotoxicity may occur due to the depletion of folate reserves and MTX-polyglutamate formation in the liver (Reference Bedoui, Guillot and Slambarom41)

[DOI] [PMC free article] [PubMed] [Google Scholar] 9.Fei J., Demillard L.J., Ren J

The dysregulation of catalase activity may disrupt cellular redox homeostasis, exacerbating oxidative damage and hastening the degeneration of dopaminergic neurons in the substantia nigra [57,58,59]
