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Furthermore, most of the tests require referral to a tertiary hospital and cannot be done in the ambulatory setting

doi: 10.1021/ja100610m

doi: 10.1371/journal.pone.0124599 42 KimYSUnnoTKimBYParkMS

FIGURE 3 Due to lack of oxygen, hypoxia leads to inhibition of prolyl hydroxylase, which is also referred as prolyl hydroxylase domain (PHD) protein