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In addition, missense mutations in WNT4 locus are associated with renal hypodysplasia in humans (Vivante et al., 2013)

In non-squamous non-small cell lung cancer (NSCLC), a phase 3 clinical trial (Impower150, NCT02366143) comparing atezolizumab (anti-PD-L1), bevacizumab (anti-VEGF), carboplatin, and paclitaxel combination therapy (ABCP group) against bevacizumab, carboplatin, and paclitaxel combination therapy (BCP group) showed significantly extended PFS and OS in the ABCP group compared with the BCP group (median PFS: 8.3 vs

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