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5-Amino-1MQ has been investigated in preclinical research in relation to nicotinamide N-methyltransferase (NNMT) inhibition and associated cellular pathways
BMJ 2003;327:55760
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Results showed that the ingredient significantly increased NAD+ levels in senescent fibroblasts, activated the SIRT1 signaling pathway, reduced the expression of senescence-associated -galactosidase (SA--gal), decreased intracellular reactive oxygen species accumulation, and promoted collagen synthesis
