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doi: 10.1016/S0026-895X(24)26443-9

Familial autoinflammation with neutrophilic dermatosis reveals a regulatory mechanism of pyrin activation

It promotes neuroplasticity in brain regions like the hippocampus by increasing BDNF levels, glutamate release, and upregulating mGLU2 receptors, particularly in the hippocampus and prefrontal cortex

Conversely, the post-translational modification via palmitoylation has been shown to increase HMGCS2 enzyme activity (Kostiuk et al., 2008
