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Whereas basal-like tumors frequently have mutations of p53 gene and therefore induce IGF-1R transcriptional upregulation, claudin-low subtypes frequently underexpress IGF-1R and closely resemble mammary epithelial stem cells expressing many of the EMT markers

Unraveling the transcriptome-based network of Tfh cells in primary Sjogren syndrome: insights from a systems biology approach

However, endocrinologists also emphasize the importance of careful patient selection, considering individual medical histories, potential drug interactions, and the presence of comorbidities such as cardiovascular disease or diabetes