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In inflammatory bowel disease models, BPC-157 reduced the severity of experimentally induced colitis in rats when administered either intraperitoneally or intraluminally, suggesting activity through both systemic and local routes (Sikiric et al., 1993

To confirm the results tendon fibroblasts were treated with BPC-157 at different concentration for 24 h, showing that the expression of GH receptor increases in dose-dependent manner causing proliferatio-promoting effect of GH which could have potential healing effect

When B12 levels fall in the indeterminate range or when clinical suspicion remains high despite normal B12 levels, additional investigations may include: Holotranscobalamin (active B12) : Available in some NHS laboratories

While larger human trials are ongoing, the science is increasingly pointing toward peptides as functional, body-aligned interventions in weight management