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Our 40 mg methyl B12 vial can take up to two hours to dissolve in 10 ml of saline

Genetic variations in methionine synthase (MTHFR) and cobalamin metabolism genes can predispose individuals to poor B12 utilization, making biomarker context clinically essential before therapy initiation

doi: 10.3389/fmed.2023.1098047 Received 17 November 2022 Accepted 02 January 2023 Published 23 January 2023 Volume 10 - 2023 Edited by Manuel Pedro Pereira, Charit Universittsmedizin Berlin, Germany Reviewed by Jan Mauno Ehrchen, University of Mnster, Germany

The difference is not in the injection itself but in the infrastructure and expertise supporting it