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Since MTX induces oxidative stress by increasing reactive oxygen species in tissues (Reference Jahovic, Cevik and Sehirli38,Reference Moghadam, Tutunchi and Namvaran-Abbas-Abad40,Reference Olayinka, Ore and Adeyemo43) , the effects of various antioxidant substances against MTX-induced oxidative stress have been investigated (Reference Savran, Cicek and Doguc7,Reference Jahovic, Cevik and Sehirli38,Reference Olayinka, Ore and Adeyemo43Reference Yuksel, Yuksel and Yagmurca45)

doi: 10.1002/dneu.22335 64 CornellBWachiTZhukarevVToyo-okaB

In addition to ganglion neuronal markers, hiPSCs-derived neurosensory progenitors expressed dorsal hindbrain marker (Pax7), otic placode marker (Pax2), preneural sensory marker (Sox2), and sensory auditory neuron markers (GATA binding protein 3, GATA3 and vesicular glutamate transporter 1, VGluT1)