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Serum markers of mitochondrial damage and death, including glutamate dehydrogenase (GDH), nuclear DNA (nDNA) and mtDNA have been investigated as clinically useful surrogate markers capable of indicating mitochondrial lysis following hepatocyte necrosis in APAP hepatotoxicity

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In iron-loaded hepcidin knockout mice, PR65 injections have a milder effect, resulting in partial redistribution of iron from the liver to the spleen

NAC reduces KYNA levels, potentially ameliorating COVID-related cognitive dysfunction (with a procognitive effect in Prefrontal circuitries)