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Non-English studies were excluded as validated translations of PD rating scales and risk-of-bias tools were not consistently available

Recent work has centered on the modulation of DA and 5-HT signaling to treat these conditions, however, the NE system, which contributes critically to the modulation of mood and attention, also remains an important target for many psychostimulant and antidepressant medications

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Tyrosine Phosphorylation Tyrosine 280 and tyrosine 301, which are both highly conserved sites in the catalytic domain of SIRT1, are key residues that are phosphorylated by Janus kinase 1 (JAK1)