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We followed the methods guidelines in the Cochrane Handbook for systematic reviews,26 the reporting guidelines in the PRISMA-NMA and PRISMA-IPD statements7 8 and evaluated credibility of findings using CINeMA.15 Compared with previous systematic reviews, we included a larger number of studies and/or studies with shared IPD, compared in a wider range of cognitive enhancers.6 27 Our results are in agreement with previous studies overall

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Safety, tolerability and pharmacokinetics of PL 14736, a novel agent for treatment of ulcerative colitis, in healthy male volunteers