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The pharmacological agent is activated at acidic pH in the gastric lumen and, after chemical modifications, it becomes reactive towards an SH group of the K + /H + -ATPase forming a mixed disulphide, which is responsible of the inhibition of the proton pump
Abstract Dysfunctions in specific subcellular organelles are fundamentally implicated in the pathogenesis of a wide range of critical diseases

The 60.3% recurrence rate after stopping suggests ongoing treatment is needed, but long-term safety data for this specific population does not exist
