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Description
Development of high-drug-loading nanoparticles
In all cases 3 technical replicates were performed for all samples/genes
Following subcutaneous injection, the peptide enters systemic circulation with bioavailability of 14-19% in rats, while intramuscular administration achieves 45-51% bioavailability in beagle dogs, indicating both route-dependent and species-dependent absorption characteristics
Copper ions alone (not the peptide) have demonstrated up to 90% inhibition of type 1 5-alpha reductase in laboratory settings
