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Drug Metab Dispos Activation of pregnane X receptor-organic anion transporting polypeptide 1a/b /P-glycoprotein/multidrug resistance protein 2 axis mediates the accelerated blood and liver clearance of PEGylated liposomes

Cell viability is generally reduced by freeze-thawing in any cell type
Atherosclerosis is the consequence of cholesterol build-up and chronic inflammation, in the context of a dysfunctional endothelium [46]

A combination of both probes thus effectively doubles the useful dynamic range without leaving a gap between the two probes
