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[4] In animals, Semax rapidly elevates the levels and expression of brain-derived neurotrophic factor (BDNF) and its signaling receptor tropomyosin receptor kinase B (TrkB) in the hippocampus, [15] and rapidly activates serotonergic and dopaminergic brain systems

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A retrospective knee-pain chart review reported that 14 of 16 contacted patients had pain relief after intra-articular BPC-157 alone or BPC-157 with thymosin beta-4, but the study was not randomized, blinded, or controlled (PubMed)

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