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Food and Drug Administration (FDA) approval of VNS in 1997 as an adjunct therapy for drugresistant epilepsy, with subsequent approvals for treatmentresistant depression in 2005, for obesity in 2015, for stroke rehabilitation in 2021, and most recently for rheumatoid arthritis (RA) in 2025 (Badran and Austelle 2022)

29 To investigate whether amino-acid supplements could counter bortezomib-induced cytotoxicity, we supplied INA-6 and ANBL-6 myeloma cell lines with alanine, cysteine or a mixture of amino acids in minimal essential medium

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