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Nrf2, as well as its family member Nrf1, plays important roles in regulating mitochondrial gene replication and protein synthesis [22]

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755 Mechanistically, SSAT1 overexpression increases ALOX15 expression and decreases the expression levels of GPX4 and SLC7A11 in primary cortical neurons, suggesting that SSAT1/ALOX15 axis activation may aggravate brain I/R injury by triggering ferroptosis in neurons

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