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This study analyzed heart samples from five pediatric male BTHS patients (5 months-15 years) and compared them to tissues from 24 non-failing donors (1971 years) using an integrated omics method combining metabolomics, lipidomics, and proteomics

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Under diabetic conditions, metabolic stressors, including chronic hyperglycemia and lipotoxicity, directly promote PANoptosome assembly by disrupting cellular energy balance, inducing mitochondrial dysfunction, and accumulating reactive oxygen species