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The timing of binders is critical

Abed M, Artunc F, Alzoubi K, Honisch S, Baumann D, Fller M, et al

10.1016/s0891-5849(02)01006-7 73 KamoshitaM.OzawaY.KubotaS.MiyakeS.TsudaC.NagaiN.et al (2014)

This quality makes it a stable gastric peptide that maintains its bioactivity whether administered orally or parenterally, allowing it to exert systemic effects