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Semaglutide activates the GLP-1 receptor (GLP-1R), a class B G-protein-coupled receptor expressed in pancreatic beta cells, the hypothalamic arcuate nucleus, the area postrema, the nucleus tractus solitarius, and vagal afferent neurons
It is naturally present in foods like meat, dairy products, and vegetables
Importantly, this highly simplified model is not meant to fully describe KAR gating, but rather to serve as a working guide for future studies
