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AOD-9604 appears to reproduce a portion of growth hormones lipolytic signaling in fat tissue increasing lipolytic sensitivity, raising fat oxidation, and restoring suppressed 3-AR expression toward normal in obese animals without engaging the growth-hormone receptor in the classical high-affinity way and without raising IGF-1

Effect of weekly subcutaneous semaglutide vs daily liraglutide on body weight in adults with overweight or obesity without diabetes: the STEP 8 randomized clinical trial

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doi: 10.1016/j.psyneuen.2021.105287