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Description
Specific aquaporins facilitate Nox-produced hydrogen peroxide transport through plasma membrane in leukaemia cells
NNMT had previously been identified as upregulated in obese adipose tissue, several solid tumours, and ageing tissue more broadly, where its activity correlates with depleted SAM and elevated 1-methylnicotinamide (MNA)
A unique structure for epidermal growth factor receptor bound to GW572016 (Lapatinib): relationships among protein conformation, inhibitor off-rate, and receptor activity in tumor cells
These interventions either block NRF2 translocation, reduce the expression of its downstream targets, or enhance oxidative damage by increasing ROS, depleting GSH, and promoting lipid peroxidation
