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10.1007/s10815-022-02625-7 113 SilveiraR
Canli, O
If OI are more opioid-tolerant than NIO, we hypothesize they would: (1) under controlled conditions, exhibit attenuated responses to a standard opioid challenge, as found in a preliminary study [46], (2) in an outpatient setting, use higher doses of illicit opioids to overcome this tolerance, (3) require higher buprenorphine concentrations to deter illicit opioid use, and (4) tolerate such higher buprenorphine concentrations without a clinically significant increase in safety problems (i.e., larger therapeutic window)
[DOI] [PubMed] 106.Pesta DH, Samuel VT
