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In addition, this isoflavone may augment glutathione synthesis by increasing the expression of -glutamylcysteine synthetase (264): the -glutamylcysteine synthetase gene is a well-studied target of Nrf-nuclear factors (both Nrf1 and Nrf2 have been implicated in its regulation) (353)

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BPC-157 also activates the ERK1/2 (extracellular signal-regulated kinase) pathway, a key signaling cascade involved in cell growth, proliferation, and survival