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Accumulation of defective mitochondria by DA modification resembling mitochondria-related abnormalities were observed in several in vitro PD modeling studies involving PINK1 or Parkin mutations thus providing a basis for what may occur in sporadic cases and how the phenotypes mimic those of familial PD cases [25, 39, 40]

In children, therapy may continue for several years until an acceptable height is achieved or until growth plates close

Moreover, pathological conditions, e.g., diarrhea that damage intestinal integrity are important contributing factors, making zinc deficiency typically the result of inadequate intake, reduced bioavailability, and increased physiological burden [30]

doi: 10.3389/fnut.2025.1746176 Received 14 November 2025 Revised 03 December 2025 Accepted 17 December 2025 Published 12 January 2026 Volume 12 - 2025 Edited by Iris Joye, University of Guelph, Canada Reviewed by Soubhagya Tripathy, Indian Institute of Technology Kharagpur, India Prakasha R., Anand Agricultural University, India Updates Copyright 2026 Hao, Tan, Liu and Xin
