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These authors have contributed equally to this work
Two signaling mechanisms are involved in the GPx1-dependent regulation of the apoptosis pathway: (1) GPx1 regulates the level of cytosolic H 2 O 2 that oxidizes the redox protein thioredoxin 1, blocking ASK1 activation, and (2) GPx1 interacts with TRAF2 and interferes with the formation of the active ASK1 complex
However, the precise enzymatic machinery responsible for Kla deposition and removal remains incompletely characterized and the relative contributions of enzymatic vs
