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The histopathological hallmark of the cuprizone model as standardized by Hiremath is oligodendrocyte death and subsequent demyelination in the corpus callosum, superior cerebellar peduncles, hippocampus [42, 4654] and several other areas of the mouse brain (reviewed in [20])
Im not calling anyone a liar I just havent been able to find any papers that the decisions to change the treatment was based on
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