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By suppressing miR-34a, SIRT1 enhances anti-inflammatory responses, prevents macrophage activation, and reduces endothelial cell dysfunction
As demonstrated by Kurimchack et al., high endogenous levels of the MDR1 protein resulted in a significant decrease in the efficacy of Cereblon-based PROTAC dBET6 when compared with PROTACs-nave cancer cells with low expression of MDR1 201
Buettner GR
