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FMO inhibitors Studies on animal models demonstrated that insulin or antisense oligonucleotide-mediated suppression of the hepatic enzyme FMO3 leads to a reduction in circulating TMAO levels and prevents hypercholesterolemia and atherosclerosis

Vegetarians and vegans who may have lower endogenous L-carnitine levels
Oil red O en face staining of the entire aorta demonstrated a reduced atherosclerotic plaque area in the HCD + ALC group compared with that of the HCD group (Figure 5A)

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