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It modulates gene expression broadly downregulating NF-B inflammatory programs while upregulating antioxidant and repair pathways
NO can also react with sulfhydryl moieties of cysteines in proteins to form S-nitrosoproteins or S-nitrosothiols in a process known as S-nitrosation, which results in a change in the activity and function of proteins

The FDA moved these peptides to Category 2 primarily due to a lack of large-scale, randomized, placebo-controlled human trials demonstrating their safety and efficacy
