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In a meta-analysis involving 11 studies, SAMe offered statistically significant support for joint function

A double-blind, randomized, counterbalanced, cross-over design was used

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The balance of prooxidants and antioxidants in the human body is heavily reliant on an adequate supply of dietary micronutrients. Important antioxidant enzymes like superoxide dismutase (SOD), glutathione peroxidase (GPx), and catalase (CAT) require cofactors in the form of trace minerals that include selenium, zinc, iron, manganese and copper to function optimally as our first line of defense against reactive oxygen species (chemically reactive molecules that contain oxygen