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Notably, researchers observed that the rise in p21 levels, a marker of senescence, was independent of p53, indicating that, unlike many previous drugs, AKI603-induced senescence may operate independently of p53 activity [79]

As shown in Table 4, over the past three decades, various clinical studies have assessed the effect of a low-histamine diet on the evolution of various symptoms, mainly dermatological, gastrointestinal and neurological, including cases with more than one type

Li L, Wu C-Y

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