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Retinoid drugs include acitretin (Soriatane) and isotretinoin (Accutane)
For example, PARP1 binds a DNA single strand break, then utilizes NAD + to ADP-ribosylate macromolecules in the vicinity, a signal for recruitment of DNA repair machinery 6
However, the peptide has been linked to changes in the hypothalamic-pituitary-adrenal axis and may influence suicidal behavior
