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The plerocercoid is the infective stage for man and other definitive hosts, including many fish-eating mammals and birds
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However, several theories have been proposed such as changes in the blood vessels that supply the peripheral nerves, metabolic and autoimmune disorders with glial cell activation, changes in sodium and calcium channel expression, and central pain mechanisms, such as increased thalamic vascularity and imbalance of the facilitatory/inhibitory descending pathways [2]
