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Indeed, one of the DKD features is the podocyte loss with consequent albuminuria (Pagtalunan et al., 1997
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Koning et al., 2025), SANS (Koning et al., 2025), and dynamic light scattering (DLS) (Hochmair et al., 2023

A landmark study by Patel et al demonstrated that even in untreated eyes, BCVA can vary by as much as 9 ETDRS letters over a 3-month interval, which is significantly higher than the 5-letter gain observed in the LIGHTSITE III trial
