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J Immunol 181(1):680689 Innamorato NG, Jazwa A, Rojo AI, Garcia C, Fernandez-Ruiz J, Grochot-Przeczek A et al (2010) Different susceptibility to the Parkinsons toxin MPTP in mice lacking the redox master regulator Nrf2 or its target gene heme oxygenase-1

Many patients return for annual appointments to monitor their response to treatment and undergo maintenance treatments if desired

Then there's the degradation of the target compound

doi: 10.1016/S0140-6736(06)69420-8 122 HomePDPocockSJBeck-NielsenHCurtisPSGomisRHanefeldMet al
