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Mammalian sirtuins--emerging roles in physiology, aging, and calorie restriction
Reactions were performed with 0.5 M catechol substrate COMT-S01, 1 M radiolabelled S-adenosyl-L-[methyl- 3 H] methionine (SAM) co-substrate, and recombinant human COMT enzyme
Combining compounds with distinct mechanisms requires careful dose titration and physiological monitoring
(2006, February)
