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Wells G, Shea B, OConnell D et al (2004) The NewcastleOttawa Scale (NOQAS) for assessing the quality of non-randomized studies in meta-analysis
Specific enzymes, MTR, methionine synthase reductase, and MTHFR, can express polymorphisms that result in elevated homocysteinemia, a risk factor for having a child with DS [106]
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Future studies are needed to capture all products pertaining to cysteine, VitB 6 , and iron, and how these impact basic biological process and pathophysiological outcomes
