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The mechanisms by which PPAR loss leads to aberrant apoptosis and reduced cell survival have been associated to altered lipid metabolism and accumulation of stress and pro-inflammatory molecules such as reactive lipids and ROS deriving from the 5-LO and COX2 pathways, that specifically activate a lipid-mediated programmed cell death [33]

J Trace Elem Med Biol 2004

Congenital hypothyroidism detected by neonatal screening: relationship between biochemical severity and early clinical features

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