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reported the TCM decoction Bu Shen Hua Zhuo formula (BSHZF) administration improved gut microbiota function in rats with letrozole-induced PCOS and inhibited the activation of the TLR4/NF-kB signaling pathway in PCOS-related ovarian tissue, decreasing the pro-inflammatory cytokines TNF-a, IL-6, and IL-8 (236)

doi: 10.3389/fphar.2019.00250 Received 24 October 2018 Accepted 26 February 2019 Published 20 March 2019 Volume 10 - 2019 Edited by Annette Nicke, Ludwig Maximilian University of Munich, Germany Reviewed by Hai Minh Nguyen, University of California, Davis, United States

Knockdown of Mfn2 leads to inhibition of mitochondrial fusion, alteration of the bioenergetic profile, and loss of osteogenic differentiation of MSCs (70)