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In BAT mitochondria, closely packed cristae might enforce prioritized CK/ANT/ATP synthase cross-talk, while loosely arranged cristae in skeletal muscle can buffer this spatial coordination requirement
However, it's only about 20-25% of the total sleep time, and often occurs in early morning

10.1016/j.bbrc.2016.03.052 132 XieY.ZhuS.SongX.SunX.FanY.LiuJ.et al (2017)

The hepatic metabolic barrier is centered on the three-layer structure of hepatic sinus-metabolizing enzyme-bile excretion
