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[DOI] [PMC free article] [PubMed] [Google Scholar] 12.Dean O., Giorlando F., Berk M

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Although small molecule or peptide-based inhibitors against individual NSPs have been extensively explored in the past 50 years, efforts of the pharmaceutical industry so far have created little impact in the clinic, except for AAT augmentation therapy in patients with emphysema and congenital AATD (191)

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elegans [166]

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Structural analysis of XChem fragment hits Four key residues implicated in the binding of TIN2 TBM to TRF1 TRFH were also commonly involved in ligand binding, namely R102, E106, Q127, and R131 (Fig

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