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Accumulation of the toxic metabolite can then exert untoward effects on key cellular structures and functions (Figure 1)

Nacamulli, D

Cognitive decline and Alzheimers disease Alzheimers disease (AD) is a form of dementia characterized by extracellular deposition of -amyloid plaques, intracellular formation of neurofibrillary tangles, and neuronal loss, eventually leading to brain atrophy and cognitive impairment in affected individuals (57)

In contrast, transferrin receptor 1 (TFRC), a key mediator of iron import, was not significantly altered in patients with MASLD (Supplemental Figure 3D), indicating that increased hepatic iron burden was more closely associated with impaired iron export rather than enhanced iron import