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The anti-inflammatory effect of choline was confirmed ex vivo, where endotoxin-activated human whole blood and macrophages exposed to supraphysiological choline concentrations (between 150 mM) exhibited reduced TNF- production (250)

A., Wolfson, M., Ahmad, S., Hirschberg, R., Kurtin, P., Katz, L

High levels of glucose can result in the production of advanced glycation end products (AGEs), which may result in protein oligomerization, oxidative stress and a pathological inflammatory response 39