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Although the overall evidence suggests that at least a subset of patients with ME/CFS exhibit reduced cortisol output, some cohorts show only modest reductions, preserved cortisol output, or context-dependent abnormalities rather than stable hypocortisolism, indicating that HPA-axis dysfunction in ME/CFS is likely heterogeneous and multifactorial rather than a specific or uniform neuroendocrine abnormality (Tomas et al., 2013

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An azide-functionalized Berberine-VQ-N (NMe) was synthesized for the click chemistry-based enrichment of modified RNAs (Supplementary Fig

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